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When reported, some of the most common side effects include: 7 Dizziness Lightheadedness Dry mouth Headache Blurred vision Nausea or vomiting Nervousness Fatigue Constipation Palpitations Rapid heart rate Low blood pressure Skin reactions, such as a rash Confusion Muscle pain. Your doctor may advise you to take your dose of trazodone once a day. Trazodone works by helping to restore the balance of a certain natural chemical (serotonin) in the brain. However, the dose is usually not more than 375 mg per day. 0 found this answer helpful | 0 lawyers agree. Purchase Trazodone (Desyrel) - low cost and price, but high quality NHS medicines information on trazodone – what it's used for, side effects, dosage and who can take it. It is in the serotonin-antagonist-and-reuptake-inhibitor class of medications. If you have diabetes, trazodone can make it more difficult to keep your blood sugar stable. 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